Czechia has a long and illustrious history of innovation, especially in what we would today call deep tech. The region that has given the world soft contact lenses, disinfectants for hospitals, and the ship propeller, today continues its legacy building equally pivotal solutions for the next-generation – new drug delivery systems, digital resilience solutions, and novel robotics platforms.
We reached out to CzechInvest to learn about the top 10 Czech deep tech startups. Thank you to Katerina Glazar Kynclova, Chief Editor and Web Content Manager, and Petr Vrana, Data Analyst, for curating the list.
As they rightly pointed out, identifying a top 10 in deep tech is tricky, since you can rank startup success by various criteria from patent portfolios and scientific breakthroughs to market traction and funding.
Keeping things data-driven, they opted for the latter, using “VC total funding as a clear and comparable benchmark”, with the additional caveats that:
“Our analysis focuses on startups founded since 2015, capturing the current wave of Czech innovation rather than long-established players. It’s also worth noting that while some standout companies such as Rossum, ThreatMark, and LIV.AI have moved their headquarters abroad, they were born in Czechia – showcasing the country’s capacity to nurture globally ambitious founders.”
Do note that the list is organized alphabetically. Without further ado, let’s dive in.
Top 10 deep tech startups from Czechia
1. Adalid Sciences
Advanced lipid nanoparticle technology enabling next-generation genomic medicine through innovative drug delivery systems.
Founded in June 2024 as a spin-off from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Adalid is dedicated to advancing pharmaceutical solutions through novel lipid nanoparticle technology. By leveraging LNPs, the company aims to enhance the stability and bioavailability of drugs, improving their therapeutic efficacy while minimizing potential side effects.
2. LIV
Mixed reality platform that allows audiences to interact with VR gameplay in real time, bridging the gap between players and spectators.
Founded in 2017, LIV is on a mission to empower creators in VR and AR to share their adventures with friends, family and fans. Founded by former competitive gamers and VR streamers, the company has become the leading VR and AR capture technology provider. LIV operates as a 100% distributed team developing solutions for the next generation of creators and game developers.
3. Neuron Soundware
AI, IoT, and edge computing solutions that analyze sound and other data to monitor and optimize the performance of industrial and energy equipment.
Founded in 2016 by Pavel Konečný through the StartupYard accelerator, the company won the Idea of the Year international award that same year for its IoT and AI concept. The platform prevents unscheduled production shutdowns, boosts productivity, and speeds up timely interventions through real-time diagnostics, while achieving energy and repair cost savings. Neuron Soundware extends machinery lifecycles through real-time failure detection and optimized maintenance plans.
4. Resistant AI
AI-powered software for document fraud detection and transaction monitoring, enhancing trust in digital finance.
Founded in 2019 and rooted in cybersecurity, the team has spent their careers studying adversaries, reverse-engineering threats, and designing systems that adapt faster than fraud. They build layered systems that question everything, including themselves, applying that discipline to financial crime prevention at scale. Resistant AI measures success in false positives avoided, fraud rings exposed, and customer trust earned – never promising 100%, but delivering on every promise made.
5. RoboTwin
No-code robotics platform for manufacturing, allowing workers to teach robots by demonstration for fast and efficient automation.
Founded in 2021 by three founders with experience in robotics, automotive, and manufacturing, RoboTwin’s vision is to become the world leader in no-code industrial robotics and close the gap between cutting-edge technologies and industry. The next wave of automation requires robots that can easily learn from humans, enabling the robotization of ever smaller series and new possibilities for using industrial robots. This approach is particularly valuable for small and medium-sized enterprises without previous experience with robotics.
6. Rossum
Intelligent document processing platform that automates transactional workflows using advanced AI.
Founded in 2017 by three AI PhD researchers who discovered a resurging business challenge: the inefficiencies of document processing. Despite advancements in technology, companies still wasted hours on manual data entry, frantic searches for missing information, and endlessly chasing approvals. Passionate about making a positive impact on people’s working lives, Rossum’s mission is to enable one person to effortlessly process one million transactions from start to finish in a year.
7. ThreatMark
Fraud prevention technology that brings trust to the digital world through advanced behavioral and transaction monitoring.
Founded in 2015 by two ethical hackers who recognized that financial institutions struggled to fight digital fraud effectively, ThreatMark developed a modern and comprehensive machine learning-based platform. The adaptable solution analyzes large amounts of data from devices, events, sessions, user behaviors, and payment transactions to help financial institutions manage the increasing risk of digital banking and evolving compliance challenges. Using the latest machine learning models, ThreatMark’s platform is easy to deploy, works out of the box, and doesn’t require any tuning of AI models.
8. Tropic Square
Digital security company designing and manufacturing open-architecture secure element chips for transparent and verifiable protection.
Founded in 2020, Tropic Square is a SatoshiLabs company and fabless semiconductor provider dedicated to redefining secure hardware through open architecture. With transparency at the core of their design philosophy, they invite customers, industry experts, and the open-source community to audit and validate their security implementations. Their RISC-V-based secure element, TROPIC01, is designed to provide the utmost security for critical applications across industries prioritizing security.
9. Vrgineers
Professional VR and MR headsets designed for pilot training and other demanding simulation environments.
Founded in 2017, Vrgineers is a leader in developing immersive technologies. The company offers high-quality and effective military pilot training using advanced XTAL Virtual and Mixed Reality headsets and aviation simulators. Vrgineers is at the forefront of cutting-edge simulation technologies, with their ultimate goal being to bridge the gap between simulation and reality, ensuring the safety of professionals in their real-life endeavors.
10. Zuri
Aerospace startup developing VTOL personal aircraft with vertical takeoff and landing capabilities.
Founded in 2017, Zuri is building VTOL aircraft to change the way people experience midrange flights – making them on-demand and door-to-door. The company enables travel on your own schedule and without airports, all secured by technology and design that doesn’t compromise on passengers’ safety and comfort. Vertical takeoff and landing allows passengers to skip airports and land everywhere from a city’s periphery to the roof of a skyscraper.
