Lithuania is cementing its commitment to becoming a major European hub for technological innovation. Once known almost exclusively for its success in the financial technology sector, especially in the mid-to-late 2010s, the country has been broadening its startup scope, and that includes tapping into the waters of deep tech.
Similar to trends across Europe, Lithuania has seen significant investment in various AI solutions, including those classified as deep tech. In 2024 alone, AI startups in Lithuania attracted €38.8 million in investments.
What’s interesting is that in April 2025, the Lithuanian government approved a key legislative initiative from the Ministry of the Economy and Innovation (EIMIN) to extend the age limit for deep tech startups seeking public support from five years to ten years. According to Vice Minister of the Economy and Innovation Marius Stasiukaitis, accelerating support for these high-tech and life science sectors is necessary to hit Lithuania’s target of dedicating 5% of GDP to life sciences.
While it may take some time for the country to see whether its legislative initiative delivers the desired results, we contacted Innovation Agency Lithuania to find out which Lithuanian deep tech startups Lithuanians themselves consider the most promising today. Karolina Urbonaite, Head of Startup Lithuania, elaborated on the selection criteria:
Startups were selected using a combination of hard data and ecosystem insight: recent VC investments, growth indicators such as team and product expansion, and Dealroom’s signal, which assesses momentum, relevance, and founder strength.
With our thanks to Karolina and Agnė Rudytė, Global Communications Manager at Innovation Agency Lithuania, here’s the list:
Top 10 deep tech startups from Lithuania
1. Atrandi Biosciences
Delivering on the long-sought promise of scalable, true single-cell multiomics.
Founded in 2016 as Droplet Genomics and rebranded into Atrandi Biosciences in 2022, this Lithuanian deep tech startup develops microfluidics tools and single-cell analysis platforms that let scientists run high-throughput experiments and generate advanced genomic data faster. Its patented Semi-Permeable Capsule (SPC) technology is a breakthrough microfluidic system that overcomes the limitations of traditional single-cell analysis by enabling multi-step, high-throughput workflows using standard lab equipment.
Atrandi Biosciences started it all with a very clear mission: to democratize biological research, and that mission has only grown since then. With a team of 70+ people, of whom >70% hold scientific degrees, the startup is on its way to making its mission a reality.
Fun fact: The company’s name, Atrandi, means “you discover” in Lithuanian.
2. nexos.ai
All-in-one AI platform for enterprises.
Another Lithuanian deep tech startup that locals talk about a lot is nexos.ai. This company provides a secure data-exchange platform allowing organizations to share sensitive information across systems while maintaining full privacy, compliance, and operational control. While relatively fresh – founded in 2024 – nexos.ai is considered one of the rising European AI stars.
nexos.ai’s platform aims to tackle the AI adoption challenges in enterprises. And with the recently raised €30M in funding, the startup is now equipped to scale its platform and decisively remove the major barriers to secure, organization-wide AI adoption.
Fun fact: nexos.ai was founded by the creators of Nord Security, a Lithuanian cybersecurity unicorn, best known for its flagship product, NordVPN.
3. Cube3.AI
Real-time fraud prevention for the speed of modern finance.
Cube3.AI is revolutionizing fraud prevention with its AI-native technology, stopping scams before they start. By combining signals from traditional and blockchain activity, Cube3.AI delivers real-time intelligence for early threat detection, providing instant alerts and fraud scoring. As the startup itself states – it doesn’t just respond to fraud, it stays ahead of the game. Founded in 2022 by an American-Lithuanian entrepreneur, Einaras Gravrock, the company raised $8.2M in seed back in 2023 and started drawing global attention with its sophisticated platform.
Fun fact: CUBE3.AI’s machine learning models are so fast and predictive that they have detected major crypto exploits, like the $28 million Penpie flash loan attack, within 32 seconds of the malicious contract being deployed, long before the funds were fully stolen.
4. Ligence
Analyzing heart ultrasound scans with the help of AI
Ever heard about AI software that helps cardiologists diagnose conditions faster and with greater accuracy? They were probably talking about Ligence. Founded in 2019, Ligence develops AI-native software for echocardiography (heart ultrasound) analysis and reporting. The startup’s main product, Ligence Heart™, is designed to streamline cardiologists’ and sonographers’ workflows by using AI to automate and simplify heart ultrasound image analysis. What’s even more impressive is that the software is FDA cleared and CE-marked, meeting regulatory standards for medical devices in the United States and Europe.
Ligence’s software is already in use by customers across Europe, including Lithuania, Poland, Switzerland, Germany, France, Spain, Portugal, and the United Kingdom, and is undergoing testing in new regions such as Morocco.
Fun fact: Ligence’s AI achieved a landmark: a European Heart Journal study showed it can surpass human cardiologist accuracy in measuring heart function against the CT gold standard.
5. Sintra
Empowering companies with AI employees (who never sleep).
With origins dating back to 2018 (while officially founded in 2023), Sintra today provides businesses with AI employees – yes, you read that right. What once started as a fun project has now become a business that serves over 40K paying customers across 100 countries. In June 2025, the startup raised $17 million in Seed.
Sintra’s AI assistants span from social media manager, email marketer, data analyst, to SEO mastermind, customer support, and more. What’s especially handy is that Sintra has plenty of tool integrations to make those workflows even more convenient.
Fun fact: Sintra’s co-founders started their first business (a marketing agency) together in a garage in Vilnius when they were just teenagers (15 and 16 years old).
6. Axiology
Revolutionizing EU capital markets with regulated digital assets.
Standing at a crossroads of fintech and deep tech in Lithuania, you’d definitely meet a startup called Axiology. A spin-off from the SUPER HOW? innovation technology lab, Axiology is building the next generation of financial infrastructure by simplifying complex capital market processes using blockchain technology. The startup operates under the EU DLT Pilot Regime, positioning it among the first regulated tokenized securities infrastructures in the EU. The Axiology founding team consists of internationally recognized experts spanning regulatory affairs, banking, and the securities market.
Fun fact: Axiology is led by CEO Dr. Marius Jurgilas, a former Member of the Bank of Lithuania’s Board, underscoring the company’s strong foundation in finance and regulation.
7. Sentante
Pioneering fully robotic, remote technology for endovascular interventions.
Another exciting Lithuanian deep tech startup, particularly in the med tech field, is Sentante. The company develops remote-controlled robotic surgery systems enabling doctors to perform precise, minimally invasive procedures from a safe distance. Sentante’s mission is “to transform healthcare by increasing treatment availability for patients and protecting medical personnel from occupational hazards,” and seeing its impressive journey since its beginnings in 2017, it’s clear that the startup has not lost its dedication at all.
Sentante’s system is designed to handle interventions in narrow, complex vessels, providing the precision needed for procedures like clot removal. Its design is validated by an FDA Breakthrough Device Designation.
Fun fact: Sentante’s teleoperated system has already performed a transatlantic remote stroke procedure, proving its ability to connect world-class specialists with patients across vast geographical distances.
8. Unmanned Defense Systems
Meeting the urgent needs of changing warfare doctrine.
Founded in 2022, Unmanned Defense Systems (UDS) is a Vilnius-based full-kill-chain ecosystem provider. Established to directly address the urgent, evolving warfare needs of NATO and allied nations, UDS was among the top 100 drone defense companies in 2025 by The Defense Post. UDS delivers advanced defense solutions centered on loitering munitions and enhanced battlefield situational awareness. The startup’s core capability is integrating AI-driven UAV swarm technology into existing Battlefield Management Systems. The company works closely with the Lithuanian and Ukrainian Armed Forces and provides its solutions to other European Union member states and NATO allies.
Fun fact: One of the UDS co-founders, Vytenis Buzas, was a creator of “Lituanica SAT-1”, Lithuania’s first satellite.
9. Astrolight
On a mission to connect Earth and Space using high-speed laser links.
Established in 2019, Astrolight develops and manufactures complete, energy-efficient optical hardware for secure, end-to-end connectivity. They power high-speed laser communication across space (LEO-to-Earth) and defense/commercial ground systems. The startup is a spin-off of the Center for Physical Sciences and Technology (FTMC) in Lithuania, and since then, it has come a long way towards successful innovations.
Astrolight is also one of the key innovators participating in the DIANA initiative, Phase 2. Earlier in 2025, the startup successfully tested its ship-to-ship laser communication terminal, POLARIS, proving that a commercially developed laser system can operate reliably in the worst-case weather and operational conditions militaries face. In May 2025, Astrolight raised €2.8 million in seed funding to accelerate development of its end-to-end laser communication platform.
Fun fact: The CTO and co-founder, Dalius Petrulionis, was a lead engineer at Light Conversion, a world-renowned manufacturer of ultra-high-power femtosecond lasers.
10. Blackswan Space
Making satellites autonomous and building a self-sustaining space economy.
Blackswan Space, founded in 2019, develops an autonomous satellite navigation system. The company’s software enables spacecraft to perform complex autonomous tasks, such as navigation, inspection, and servicing (RPO). This capability reduces the need for human ground intervention, cutting costs and extending the operational life of orbiting assets.
The startup founders have emphasized that this independence from ground control is essential, as human operators won’t be able to manage the sheer volume of satellites launching in the near future. Blackswan Space’s technology has been validated through several programs, including the European Space Agency (ESA) Business Incubation Centre.
Fun fact: Blackswan Space’s technology is being perfected in the most contested area – Low Earth Orbit (LEO) – but its ultimate goal is to enable missions to the Moon and Mars.
